Coming back from an excellent time (and an excellent talk, updated slides here) out at SxSw Interactive, I've been thinking once more as always about what it really takes to get Drupal "to the next level."
Clearly there are multiple fronts we are proceeding along as a community. The amazing development work being done in core and contrib is obviously key, as are the boundary-pushing efforts to integrate more and better infrastructure for enterprise-scale use-cases, as is the continuing drive to test everything in an automated/continuous basis. However, I wanted to throw out yet another thing we should be thinking about as a development community: monitoring.
Now to be clear, I'm not talking about what you can get out of Munin (although that's nice). It's good to know your server load, but what I really care about is my page execution time, my per-bootstrap memory consumption, my most-frequently run (or longest running) queries. Many of the pieces are there in terms of code already written into the devel module and others, but we don't have anything to compare with what other platforms are doing to expose the internal metrics of their application:

In addition to being great eye-candy, this kind of monitoring gives people running large sites (or large numbers of sites) the kind of confidence they need to see "at a glance" that things are ok. It also helps engineers like me spot problems and troubleshoot issues without having to add intrusive changes to live environments.
There's always more to be done, and this is something we'll be thinking about long and hard as part of the PANTHEON project in 2010. As Drupal continues to mature as a platform technology, the addition of supporting services like monitoring (and more advanced analytics) will be important paths for development.
(Update: thanks for the editorial support from Adrian, who notes that "Enterprise Drupal needs spellcheck.")
I will be trying Server Density soon for server monitoring. Easy on the eyes and less work than Munin. Paired with Pingdom and this should be enough monitoring for most. Not sure if these services meet your enterprise needs. They are affordable, easy to setup and attractive, which is more than can be said about most other options.